Reference-panel ancestry sensitivity
#2
by Shicheng - opened
The GWASLab reference collection standardizes LD, allele-frequency, strand-inference, and rsID resources across multiple 1000 Genomes super-populations and genome builds. In practice, how do you recommend quantifying the sensitivity of fine-mapping or polygenic scores to ancestry-matched versus pan-ancestry reference panels, particularly for underrepresented biobank populations?